PW01-006 – The effect of colchicine on physical growth in FMF

Results Patients, 22 (43.1%) were male and 29 (56.9%) were female with age of disease onset 5 (1-10) years, age of diagnosis and onset of therapy were 6.4 (1.3 to 11) years. According to Tel Hashomer criteria, severity score of the disease was 7 (4-10). When compered of height and weight of the patients at the beginning and at the one year of colchicine treatment a significant increase was found (p<0,05). Height SDS ‘s increased from -0.6 to -0.2; weight SDS’ s increased from -0.6 to -0.4. The participants’ BMI SDS didn’t showed a significant increase, both the weight and height SDS proceedings of the increase was associated with, so it is possible there was no significant increase. The patients’, who had no episode, height and weight SDS increased more than who had episode. There was no effect of disease severity on growth (p> 0.05). Also height gain was not affected from elevated acute phase reactans at the attack free period, weight gain did. Body weight and body surface of the patients receiving doses of colchicine were averaged 0.03 ± 0.02 mg / kg / day was 0.98 ± 0.045 mg/m. Colchicine dose was the same in patients with or without any attack.